Jan Christoph, PhD, MSc

Assistant Professor

Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

Publications

  1. Apfelbacher T, Koçman SE, Negash S, Manuilova I, Mang JM, Papon H, Mikolajczyk R, Prokosch HU, Christoph J. Utilization of Broad Consent as an Effective Instrument for Study Recruitment. Studies in health technology and informatics 2025. PMID: 40899529


  2. Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE. AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome. European heart journal 2025. PMID: 40884219


  3. Manuilova I, Bossenz J, Weise AB, Boehm D, Döbel M, Werle SD, Ustjanzew A, Reimer N, Strantz C, Unberath P, Metzger P, Pauli T, Schulze S, Hiemer S, Oguztürk I, Kamkar L, Kestler HA, Busch H, Brors B, Christoph J. Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review. Journal of medical Internet research 2025. PMID: 40824687


  4. Boehm D, Reimer N, Christoph J, Scheiter A, Unberath P. Building a Knowledge Base for Variant Annotation Using Therapy Recommendations in cBioPortal. Studies in health technology and informatics 2025. PMID: 40380393


  5. Bossenz J, Manuilova I, Weise AB, Schulze S, Hiemer S, Eszlinger M, Boerries M, Busch H, Boehm D, Unberath P, Reimer N, Strantz C, Christoph J. Prototypical Visualization of Patient Similarities in cBioPortal to Enhance Decision-Making in Molecular Tumor Boards. Studies in health technology and informatics 2025. PMID: 40380495


  6. Strantz C, Böhm D, Ganslandt T, Börries M, Metzger P, Pauli T, Blaumeiser A, Scheiter A, Jung IC, Christoph J, Manuilova I, Strauch K, Ustjanzew A, Reimer N, Busch H, Unberath P. Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards. BMC medical informatics and decision making 2025. PMID: 39819625


  7. Manuilova I, Bossenz J, Weise AB, Boehm D, Strantz C, Unberath P, Reimer N, Metzger P, Pauli T, Werle SD, Schulze S, Hiemer S, Ustjanzew A, Kestler HA, Busch H, Brors B, Christoph J. Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review. JMIR research protocols 2024. PMID: 39230952


  8. Baranwal T, Lebert J, Christoph J. Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models. APL machine learning 2024. PMID: 39364376


  10. Boehm D, Strantz C, Christoph J, Busch H, Ganslandt T, Unberath P. Data Visualization Support for Tumor Boards and Clinical Oncology: Protocol for a Scoping Review. JMIR research protocols 2024. PMID: 38441925


  11. Renner C, Reimer N, Christoph J, Busch H, Metzger P, Boerries M, Ustjanzew A, Boehm D, Unberath P. Extending cBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study. JMIR medical informatics 2023. PMID: 38079196


  12. Christoph J, Ripplinger CM. Paralysis by analysis: Overcoming cardiac contraction with computer vision. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37792520


  13. Metzger P, Hess ME, Blaumeiser A, Pauli T, Schipperges V, Mertes R, Christoph J, Unberath P, Reimer N, Scheible R, Illert AL, Busch H, Andrieux G, Boerries M. MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making. Cancers 2023. PMID: 37444566


  14. Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS. Optical mapping of contracting hearts. The Journal of physiology 2023. PMID: 36866700


  15. M?nkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C. Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023. PMID: 35989424


  17. Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N. N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy. Gastroenterology 2022. PMID: 36402190


  18. Lebert J, Ravi N, Kensah G, Christoph J. Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking. Frontiers in cardiovascular medicine 2022. PMID: 35686036


  19. Unberath P, Mahlmeister L, Reimer N, Busch H, Boerries M, Christoph J. Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles. Applied clinical informatics 2022. PMID: 35354211


  20. Ustjanzew A, Desuki A, Ritzel C, Dolezilek AC, Wagner DC, Christoph J, Unberath P, Kindler T, Faber J, Marini F, Panholzer T, Paret C. cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. BMC medical informatics and decision making 2021. PMID: 34930224


  21. Lebert J, Ravi N, Fenton FH, Christoph J. Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks. Frontiers in physiology 2021. PMID: 34975536


  22. Reimer N, Unberath P, Busch H, Börries M, Metzger P, Ustjanzew A, Renner C, Prokosch HU, Christoph J. Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform. Studies in health technology and informatics 2021. PMID: 34795098


  23. Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics 2021. PMID: 33859764


  25. Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J. High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts. Frontiers in physiology 2020. PMID: 32528304


  26. Kunz M, Jeromin J, Fuchs M, Christoph J, Veronesi G, Flentje M, Nietzer S, Dandekar G, Dandekar T. In silico signaling modeling to understand cancer pathways and treatment responses. Briefings in bioinformatics 2020. PMID: 31117120


  27. Buechner P, Hinderer M, Unberath P, Metzger P, Boeker M, Acker T, Haller F, Mack E, Nowak D, Paret C, Schanze D, von Bubnoff N, Wagner S, Busch H, Boerries M, Christoph J. Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. Diagnostics (Basel, Switzerland) 2020. PMID: 32050609


  28. Lebert J, Christoph J. Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media. Chaos (Woodbury, N.Y.) 2019. PMID: 31575136


  29. Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M. β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma. International journal of cancer 2019. PMID: 30653264


  31. Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S. Electromechanical vortex filaments during cardiac fibrillation. Nature 2018. PMID: 29466325


  32. Christoph J, Schröder-Schetelig J, Luther S. Electromechanical optical mapping. Progress in biophysics and molecular biology 2017. PMID: 28947080


  33. Lilienkamp T, Christoph J, Parlitz U. Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves. Physical review letters 2017. PMID: 28949756


  34. Richter C, Christoph J, Lehnart SE, Luther S. Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias. Methods in molecular biology (Clifton, N.J.) 2016. PMID: 26965131